TY  - GEN 
AU  - Castillo, Francisco
AU  - Corbi Verge, Carles
AU  - Murciano Calles, Javier
AU  - Candel, Adela M.
AU  - Iglesias Bexiga, Manuel
AU  - Ruiz Sanz, Javier
AU  - Martínez Herrerías, José Cristóbal
AU  - Luque Fernández, Irene
PY  - 2022
UR  - http://hdl.handle.net/10481/74732
AB  - The recognition of PPxY viral Late domains by the third WW domain of the human HECT-E3 ubiquitin ligase
NEDD4 (NEDD4-WW3) is essential for the budding of many viruses. Blocking these interactions is a promising
strategy to develop broad-spectrum...
LA  - eng
PB  - Elsevier
KW  - NEDD4
KW  - WW domains
KW  - NEDD4-WW3 domain
KW  - Drug discovery
KW  - Polyproline recognition
KW  - Broad-spectrum antivirals
KW  - Phage display
KW  - Molecular dynamics simulations
KW  - Calorimetry
KW  - Nuclear magnetic resonance
TI  - Phage display identification of nanomolar ligands for human NEDD4-WW3: Energetic and dynamic implications for the development of broad-spectrum antivirals
DO  - 10.1016/j.ijbiomac.2022.03.010
ER  -