TY - GEN AU - Picón Ruiz, Manuel AU - Qureshi, Rehana AU - Aurrekoetxea-Rodriguez, Iskander AU - Nunes de Paiva, Vanessa AU - D’Amico, Massimo AU - Yoon, Hyunho AU - Radhakrishnan, Ramya AU - Morata-Tarifa, Cynthia AU - Ince, Tan AU - Lippman, Marc E. AU - Thaller, Seth R. AU - Rodgers, Steven E. AU - Kesmodel, Susan AU - Vivanco, Maria del Mar AU - Slingerland, Joyce M. PY - 2020 UR - http://hdl.handle.net/10481/73671 AB - Many inflammation-associated diseases, including cancers, increase in women after menopause and with obesity. In contrast to anti-inflammatory actions of 17β-estradiol, we find estrone, which dominates after menopause, is pro-inflammatory. In human... LA - eng KW - Obesity KW - Adipocytes KW - Cytokines KW - NFκB KW - Estrone KW - 17β-estradiol KW - Inflammation KW - ER+ breast cancer KW - HSD17B14 KW - Cancer stem cells Obesity TI - The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development DO - 10.1016/j.cmet.2020.05.008 ER -