TY - JOUR AU - Szczepanska, Katarzyna AU - Ruiz Cantero, María del Carmen AU - Cobos del Moral, Enrique José PY - 2021 UR - http://hdl.handle.net/10481/72485 AB - In an attempt to extend recent studies showing that some clinically evaluated histamine H3 receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we selected 20 representative structures among our previously reported... LA - eng PB - American Chemical Society KW - Histamine H3 receptor KW - Sigma-1 receptor KW - Sigma-2 receptor KW - Piperazine derivatives KW - Piperidine derivatives KW - Dual targeting compounds KW - Molecular docking KW - Dynamics KW - Functional characterization TI - Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma‑1 Receptor Antagonists with Promising Antinociceptive Properties DO - 10.1021/acschemneuro.1c00435 ER -