TY - JOUR AU - Martí, Juan Manuel AU - García Díaz, Ángel AU - Delgado Bellido, Daniel AU - O'Valle Ravassa, Francisco Javier AU - González Flores, Ariannys AU - Oliver Pozo, Francisco Javier PY - 2021 UR - http://hdl.handle.net/10481/69143 AB - Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/ activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness... LA - eng PB - Elsevier KW - Hypoxia KW - PARP-1 KW - PARylation KW - ChIP-seq KW - Tumor microenvironment TI - Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions DO - 10.1016/j.redox.2021.101885 ER -