TY  - JOUR 
AU  - Modi, Tushar
AU  - Risso, Valeria Alejandra
AU  - Martínez Rodríguez, Sergio
AU  - Gavira Gallardo, José Antonio
AU  - Sánchez Ruiz, José Manuel
PY  - 2021
UR  - http://hdl.handle.net/10481/68647
AB  - TEM-1 β-lactamase degrades β-lactam antibiotics with a strong preference for penicillins.
Sequence reconstruction studies indicate that it evolved from ancestral enzymes that
degraded a variety of β-lactam antibiotics with moderate efficiency. This...
LA  - eng
PB  - Nature
TI  - Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
DO  - 10.1038/s41467-021-22089-0
ER  -