TY  - GEN 
AU  - Hung, Chi-Fa
AU  - Breen, Gerome
AU  - Czamara, Darina
AU  - Corre, Tangury
AU  - Wolf, Christiane
AU  - Kloiber, Stefan
AU  - Bergmann, Sven
AU  - Craddock, Nick
AU  - Gill, Michael
AU  - Holsboer, Florian
AU  - Jones, Lisa
AU  - Jones, Ian
AU  - Korszun, Ania
AU  - Kutalik, Zoltan
AU  - Lucae, Susanne
AU  - Maier, Wolfgang
AU  - Mors, Ole
AU  - Owen, Michael J.
AU  - Rice, John
AU  - Rietschel, Marcella
AU  - Uher, Rudolf
AU  - Vollenweider, Peter
AU  - Waeber, Gerard
AU  - Craig, Ian W.
AU  - Farmer, Anne E.
AU  - Lewis, Cathryn M.
AU  - Müller-Myhsok, Bertram
AU  - Preisig, Martin
AU  - McGuffin, Peter
AU  - Rivera Sánchez, Margarita
PY  - 2015
SN  - 1741-7015
UR  - http://hdl.handle.net/10481/35976
AB  - Background:

Obesity is strongly associated with major depressive disorder (MDD) and various other diseases. Genome-wide association studies have identified multiple risk loci robustly associated with body mass index (BMI). In this study, we aimed...
AB  - Methods:

Linear and logistic regression models were conducted to predict BMI and obesity, respectively, in three independent large case–control studies of major depression (Radiant, GSK-Munich, PsyCoLaus). The analyses were first performed in the...
AB  - Results:

In the discovery phase, a total of 2,521 participants (1,895 depressed patients and 626 controls) were included from the Radiant study. Both unweighted and weighted GRS were highly associated with BMI (P <0.001) but explained only a modest...
AB  - Conclusions:

A GRS proved to be a highly significant predictor of obesity in people with MDD but accounted for only modest amount of variance. Nevertheless, as more risk loci are identified, combining a GRS approach with information on non-genetic...
LA  - eng
PB  - Biomed Central
KW  - Body mass index
KW  - Genetic risk score
KW  - Major depressive disorder
KW  - Obesity
TI  - A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder
DO  - 10.1186/s12916-015-0334-3
ER  -