TY  - GEN 
AU  - Moreno-López, Laura
AU  - Stamatakis, Emmanuel A.
AU  - Fernández-Serrano, María José
AU  - Gómez Río, Manuel
AU  - Rodríguez Fernández, Antonio
AU  - Pérez García, Miguel
AU  - Verdejo García, Antonio Javier
PY  - 2012
SN  - 1932-6203
UR  - http://hdl.handle.net/10481/30946
AB  - Introduction

Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings from such studies may...
AB  - Methods

Our sample consisted of 49 polysubstance users enrolled in residential treatment. We conducted correlation analyses between estimates of use of cocaine, heroin, alcohol, MDMA and cannabis and brain metabolism (BM) (using Statistical...
AB  - Results

The analysis showed significant negative correlations between severity of heroin, alcohol, MDMA and cannabis use and BM in the dorsolateral prefrontal cortex (DLPFC) and temporal cortex. Alcohol use was further associated with lower...
AB  - Conclusions

Duration of use of different drugs negatively correlated with overlapping regions in the DLPFC, whereas severity of cocaine, heroin and alcohol use selectively impact parietal, temporal, and frontal-premotor/basal ganglia regions...
LA  - eng
PB  - Public Library of Science (PLOS)
KW  - Alcohols
KW  - Cannabis
KW  - Cocaine
KW  - Drug metabolism
KW  - Drug users
KW  - Heroin
KW  - Neuroimaging
KW  - Positron emission tomography
TI  - Neural Correlates of the Severity of Cocaine, Heroin, Alcohol, MDMA and Cannabis Use in Polysubstance Abusers: A Resting-PET Brain Metabolism Study
ER  -