TY  - GEN 
AU  - Lavarino, Cinzia
AU  - Cheung, Nai-Kong V.
AU  - García, Idoia
AU  - Domenech, Gema
AU  - Torres, Carmen de
AU  - Alaminos Mingorance, Miguel
AU  - Ríos, José
AU  - Gerald, William L.
AU  - Kushner, Brian
AU  - LaQuaglia, Mike
AU  - Mora, Jaume
PY  - 2009
SN  - 1471-2407
UR  - http://hdl.handle.net/10481/30774
AB  - Background: Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission,
especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from
lethal stage 4 can be difficult, but critical for...
AB  - Methods: Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage
4s), were evaluated by allelic and gene expression analyses.
AB  - Results: All stage 4s patients underwent spontaneous remission, only 48% stage 4 patients
survived despite combined modality therapy. Stage 4 tumours were 90% near-diploid/tetraploid,
44% MYCN amplified, 77% had 1p LOH (50% 1p36), 23% 11q and/or 14q...
AB  - Conclusion: Specific chromosomal aberrations are associated with distinct gene expression
profiles which characterize spontaneously regressing or aggressive infant NB, providing the
biological basis for the distinct clinical behaviour.
LA  - eng
PB  - Biomed Central
KW  - Chromosome aberrations
KW  - Gene expression profiling
KW  - Neoplastic
KW  - Neoplasm staging
KW  - Neoplastic processes
KW  - Neuroblastoma
TI  - Specific gene expression profiles and chromosomal abnormalities  are associated with infant disseminated neuroblastoma
ER  -