TY  - JOUR 
AU  - Perales Romero, Sonia
AU  - Alejandre Pérez, María José
AU  - Palomino Morales, Rogelio
AU  - Torres, Carolina
AU  - Linares Gil, Ana
PY  - 2010
SN  - 1476-511X
UR  - http://hdl.handle.net/10481/29688
AB  - Background

Nutritional control of gene regulation guides the transformation of smooth muscle cells (SMC) into foam cells in atherosclerosis. Oxidative stress has been reported in areas of lipid accumulation, activating proliferation genes....
AB  - Methods

An in vivo/in vitro cell model was used, culturing SMC isolated from chicks exposed to an atherogenic cholesterol-rich diet with 5% of cholesterol (SMC-Ch) alone or followed by an anti-atherogenic fish oil-rich diet with 10% of menhaden oil...
AB  - Conclusion

Replacement of a cholesterol-rich diet with a fish oil-rich diet produces some reversal of the cholesterol-induced changes, increasing the resistance of SMC to apoptosis.
LA  - eng
PB  - Biomed Central
KW  - Atherosclerosis
KW  - Fatty acids
KW  - Apoptosis
KW  - Cholesterol
KW  - Diet
KW  - Fish oils
KW  - Foam cells
KW  - Tumor suppressor protein p53
TI  - Fish oil supplementation reverses the effect of cholesterol on apoptotic gene expression in smooth muscle cells
ER  -