TY  - GEN 
AU  - Jiménez-Medina, Eva
AU  - García Lora, Ángel Miguel
AU  - Paco Mateu, Laura
AU  - Algarra López, Ignacio
AU  - Collado, Antonia
AU  - Garrido Torres-Puchol, Federico
PY  - 2006
SN  - 1471-2407
UR  - http://hdl.handle.net/10481/29164
AB  - Background
Phytopharmacological studies of different Calendula extracts have shown anti-inflamatory, anti-viral and anti-genotoxic properties of therapeutic interest. In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory...
AB  - Methods
An aqueous extract of Calendula Officinalis was obtained by a novel extraction method in order to measure its anti-tumor and immunomodulatory activities in vitro. Tumor cell lines derived from leukemias, melanomas, fibrosarcomas and cancers...
AB  - Results
The LACE extract showed a potent in vitro inhibition of tumor cell proliferation when tested on a wide variety of human and murine tumor cell lines. The inhibition ranged from 70 to 100%. Mechanisms of inhibition were identified as cell cycle...
AB  - Conclusion
These results indicate that LACE aqueous extract has two complementary activities in vitro with potential anti-tumor therapeutic effect: cytotoxic tumor cell activity and lymphocyte activation. The LACE extract presented in vivo...
LA  - eng
PB  - Biomed Central
KW  - Plant extracts
KW  - Antineoplastic
KW  - Apoptosis
KW  - Calendula
KW  - Lymphocyte activation
KW  - Neoplasm transplantation
TI  - A new extract of the plant calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation
ER  -