TY  - GEN 
AU  - Arias Bordajandi, Fabio
AU  - Sixto-López, Yudibeth
AU  - Richard, Koral S. E.
AU  - Das, Sandeep
AU  - Anand, Sumit K.
AU  - Luque Navarro, Pilar María
AU  - Bañuelos Sánchez, Guillermo
AU  - Pacheco García, Juan Luis
AU  - Gade, Reethika
AU  - McKinney, M. Peyton
AU  - Kumar, Dhananjay
AU  - Maxie, Jemiah
AU  - Corr, W. Rylan
AU  - Pandey, Nilesh
AU  - Kaur, Harpreet
AU  - Ding, Jibin
AU  - Tan, Lin
AU  - Scott, Elisha
AU  - Nam, Hyung
AU  - Gottlieb, Eyal
AU  - Orr, A. Wayne
AU  - Dhanesha, Nirav
AU  - Yurdagul, Arif
AU  - Pey Rodríguez, Ángel Luis
AU  - Franco Montalbán, Francisco
AU  - Gómez Vidal, José Antonio
AU  - Rom, Oren
AU  - Díaz Gavilán, Mónica
PY  - 2026
UR  - https://hdl.handle.net/10481/111200
AB  - Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder caused by hepatic oxalate overproduction due to alanine-glyoxylate aminotransferase (AGXT) deficiency. Therapeutic strategies targeting glycolate oxidase (GO) and lactate dehydrogenase A...
LA  - eng
PB  - American Chemical Society
KW  - Primary Hyperoxaluria
KW  - Dual Inhibitors
KW  - Glycolate Oxidase
KW  - Lactate Dehydrogenase
KW  - Hydrophobic Tag
KW  - Targeted Protein Degradation
KW  - Oxalate Reduction
KW  - Oxalate
KW  - small molecule
TI  - Targeting Oxalate Production by Combining Enzyme Inhibition and Proteolysis Activation: A Novel Therapeutic Approach for Primary Hyperoxaluria Type 1
DO  - 10.1021/acs.jmedchem.5c02055
ER  -