TY  - GEN 
AU  - Kopp, Nicole
AU  - Catapano, Carlo
AU  - Civenni, Gianluca
AU  - Laurini, Erik
AU  - Pricl, Sabrina
AU  - Humpf, Hans-Ulrich
AU  - Almansa, Carmen
AU  - Nieto López, Francisco Rafael
AU  - Schepmann, Dirk
AU  - Wünsch, Bernhard
PY  - 2021
UR  - https://hdl.handle.net/10481/110313
AB  - 1,3-Dioxanes 1 and cyclohexanes 2 bearing a phenyl ring and an aminoethyl moiety in 1,3-relationship to each other represent highly potent σ1 receptor antagonists. In order to increase the chemical stability of the acetalic 1,3-dioxanes 1 and the...
AB  - Los 1,3-dioxanos 1 y los ciclohexanos 2, con un anillo fenilo y una fracción aminoetilo en relación 1,3, representan antagonistas muy potentes del receptor sigma-1. Para aumentar la estabilidad química de los 1,3-dioxanos acetálicos 1 y la polaridad...
LA  - eng
PB  - Elsevier
KW  - sigma-1 receptor
KW  - 2,6-disubstituted tetrahydropyrans
KW  - chemoenzymatic synthesis
KW  - chiral HPLC
KW  - antitumor activity
KW  - antiallodynic activity
TI  - Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity
DO  - 10.1016/j.ejmech.2021.113443
ER  -