TY  - GEN 
AU  - Bechthold, Elena
AU  - Schreiber, Julian A
AU  - Ritter, Nadine
AU  - Schepmann, Dirk
AU  - Daniliuc, Constantin
AU  - González Cano, Rafael
AU  - Nieto López, Francisco Rafael
AU  - Seebohm, Guiscard
AU  - Wünsch, Bernhard
PY  - 2022
UR  - https://hdl.handle.net/10481/110213
AB  - Siguiendo el concepto de restricción conformacional para obtener ligandos σ1 de alta afinidad, el anillo de piperidina del eliprodil se sustituyó por el sistema tropano bicíclico y se introdujo un doble enlace exocíclico. Los bencilidenetropanos 9...
AB  - Following the concept of conformational restriction to obtain high affinity σ1 ligands, the piperidine ring of eliprodil was replaced by the bicyclic tropane system and an exocyclic double bond was introduced. The envisaged benzylidenetropanes 9 were...
LA  - eng
PB  - Elsevier Ltd
KW  - sigma-1 receptors
KW  - conformatonal restriction
KW  - tropanes
KW  - stereochemistry
KW  - antiallodynic activity
TI  - Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity
DO  - https://doi.org/10.1016/j.ejmech.2022.114113
ER  -