TY  - GEN 
AU  - Blicker, Luca
AU  - González Cano, Rafael
AU  - Laurini, Erik
AU  - Nieto, Francisco R
AU  - Schmidt, Judith
AU  - Schepmann, Dirk
AU  - Pricl, Sabrina
AU  - Wünsch, Bernhard
PY  - 2023
UR  - https://hdl.handle.net/10481/109850
AB  - Antagonists at σ1 receptors have great potential for the treatment of neuropathic pain. Starting from monoterpene (−)-isopulegol (1), aminodiols 8−11 were obtained and transformed into bicyclic 13−16 andtricyclic ligands 19−22. Aminodiols 8−11 showed...
AB  - Los antagonistas de los receptores σ1 poseen un gran potencial para el tratamiento del dolor neuropático. Partiendo del monoterpeno (−)-isopulegol (1), se obtuvieron los aminodioles 8–11, los cuales fueron transformados en ligandos bicíclicos 13–16 y...
LA  - eng
PB  - American Chemical Society (ACS)
KW  - σ1 receptor antagonists
KW  - isopulegol
KW  - neoisopulegol
KW  - monoterpenes
KW  - chiral pool synthesis
KW  - stereochemistry
KW  - conformational restriction
KW  - docking studies
KW  - molecular dynamics simulations
KW  - antiallodynic activity
KW  - S1RA
KW  - PRE-084
TI  - Conformationally restricted σ1 receptor antagonists from (–)-isopulegol
DO  - 10.1021/acs.jmedchem.2c02081
ER  -