TY  - GEN 
AU  - Zafra, María Paz
AU  - Schatoff, Emma M.
AU  - Katti, Alyna
AU  - Foronda, Miguel
AU  - Breinig, Marco
AU  - Schweitzer, Anabel Y.
AU  - Simon, Amber
AU  - Han, Teng
AU  - Goswami, Sukanya
AU  - Montgomery, Emma
AU  - Thibado, Jordana
AU  - Kastenhuber, Edward R.
AU  - Sánchez-Rivera, Francisco J.
AU  - Shi, Junwei
AU  - Vakoc, Christopher R.
AU  - Lowe, Scott W.
AU  - Tschaharganeh, Darjus F.
AU  - Dow, Lukas E.
PY  - 2018
UR  - https://hdl.handle.net/10481/109751
AB  - CRISPR base editing enables the creation of targeted single-base conversions without generating double-stranded breaks. However, the efficiency of current base editors is very low in many cell types. We reengineered the sequences of BE3, BE4Gam, and...
LA  - eng
PB  - Springer Nature
KW  - CRISPR-Cas9
KW  - Base Editing
KW  - Organoids
KW  - Cancer-associated mutations
KW  - Mouse models
TI  - Optimized base editors enable efficient editing in cells, organoids and mice
DO  - 10.1038/nbt.4194
ER  -