TY - GEN AU - Nag, Shalini AU - Ma, Qing AU - Wang, Hui AU - Chumnarnsilpa, Sakesit AU - Lee, Wei Lin AU - Larsson, Marten AU - Kannan, Balakrishnan AU - Hernández-Valladares, María AU - Burtnick, Leslie D. AU - Robinson, Robert C. PY - 2009 UR - https://hdl.handle.net/10481/109742 AB - Gelsolin consists of six homologous domains (G1-G6), each containing a conserved Ca-binding site. Occupation of a subset of these sites enables gelsolin to sever and cap actin filaments in a Ca-dependent manner. Here, we present the structures of... LA - eng PB - PNAS KW - Actin KW - Calcium activated KW - Calcium dependent KW - TIRF TI - Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin DO - 10.1073/pnas.0812374106 ER -