TY - GEN AU - Hu, Zhaoqing AU - Matsuo, Hitoshi AU - Du, Shangce AU - Berzain Battion, Cecilia AU - Jassowicz, Lena AU - Carretero, Rafael AU - Sator-Schmit, Melanie AU - Zhao, Xiyue AU - Miao, Beiping AU - Eris, Cansu AU - Engel, Helena AU - Mahmoud, Mohamed A.A. AU - Lapor, Elke AU - Xiao, Yanling AU - Hofmann, Ilse AU - Herold-Mende, Christel AU - Sun, Chong PY - 2025 UR - https://hdl.handle.net/10481/108582 AB - Extracellular ATP (eATP) accumulates substantially in the tumor microenvironment (TME) and rises further during immunotherapy. While canonically an immune-activating “danger” signal, eATP also promotes immunosuppression in tumors, thus far largely... LA - eng PB - bioRxiv KW - P2RY2 KW - Immunotherapy KW - ATP TI - P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy DO - 10.1101/2025.10.09.681049 ER -