TY  - GEN 
AU  - Mowat, Jeffrey
AU  - Carretero Coca, Rafael
AU  - Leder, Gabriele
AU  - Aiguabella Font, Nuria
AU  - Neuhaus, Roland
AU  - Berndt, Sandra
AU  - Günther, Judith
AU  - Friberg, Anders
AU  - Schäfer, Martina
AU  - Briem, Hans
AU  - Raschke, Marian
AU  - Miyatake Ondozabal, Hideki
AU  - Buchmann, Bernd
AU  - Boemer, Ulf
AU  - Kreft, Bertolt
AU  - Hartung, Ingo V.
AU  - Offringa, Rienk
PY  - 2024
UR  - https://hdl.handle.net/10481/107597
AB  - Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) is a serine/threonine kinase that acts as an immune checkpoint downstream of T-cell receptor stimulation. MAP4K1 activity is enhanced by prostaglandin E2 (PGE2) and transforming growth...
LA  - eng
PB  - American Chemical Society
KW  - Drug discovery
KW  - Cancer
KW  - Immunotherapy
KW  - MAP4K1
TI  - Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T-Cell Immunity against Cancer
DO  - 10.1021/acs.jmedchem.4c01325
ER  -