TY  - GEN 
AU  - Sixto López, Yudibeth
AU  - Mendoza-Figueroa, Humberto L.
AU  - Landeros-Rivera, Bruno
AU  - Camacho-Molina, Alejandra
AU  - Correa-Basurto, José
PY  - 2025
UR  - https://hdl.handle.net/10481/103889
AB  - Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid disorder caused by a
deficiency in CYP27A1, the first enzyme in the bile acid biosynthesis pathway. CYP27A1 catalyzes the
7α-hydroxylation of cholesterol, playing an important role...
LA  - eng
PB  - Springer Nature
KW  - CYP27A1
KW  - Molecular dynamics simulations
KW  - Cerebrotendinous xanthomatosis
TI  - Molecular dynamics, docking and quantum calculations reveal conformational changes influenced by CYP271A amino acid mutations related to cerebrotendinous xanthomatosis
DO  - 10.1038/s41598-025-93966-7
ER  -