TY  - GEN 
AU  - Han, Teng
AU  - Schatoff, Emma M
AU  - Murphy, Charles
AU  - Zafra, Maria Paz
AU  - Wilkinson, John E.
AU  - Elemento, Olivier
AU  - Dow, Lukas E
PY  - 2017
UR  - https://hdl.handle.net/10481/100421
AB  - Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted therapies. Chromosome rearrangements are a common feature of human malignancies, but whether they represent bona fide cancer...
LA  - eng
PB  - Nature
KW  - R-Spondin
KW  - chromosome rearrangements
KW  - Colorectal cancer
KW  - WNT
KW  - CRISPR-Cas9
TI  - R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
DO  - 10.1038/ncomms15945.
ER  -