TY  - GEN 
AU  - Cronin, Shane J. F.
AU  - Rao, Shuan
AU  - Tejada Giráldez, Miguel Ángel
AU  - Turnes, Bruna Lenfers
AU  - Licht-Mayer, Simon
AU  - Omura, Takao
AU  - Brenneis, Christian
AU  - Jacobs, Emily
AU  - Barret, Lee
AU  - Latremoliere, Alban
AU  - Andrews, Nick A.
AU  - Channon, Keith M.
AU  - Latini, Alexandra
AU  - Arvanites, Anthony C.
AU  - Davidow, Lance S.
AU  - Costigan, Michael
AU  - Rubin, Lee L.
AU  - Penninger, Josef M.
AU  - Woolf, J. Woolf
PY  - 2022
UR  - https://hdl.handle.net/10481/100393
AB  - Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human...
LA  - eng
PB  - American Association for the Advancement of Science
TI  - Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer
DO  - 10.1126/scitranslmed.abj1531
ER  -