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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/99197">
      <dc:title>Optimization of a Sonotrode Extraction Method and New Insight of Phenolic Composition of Fucus vesiculosus</dc:title>
      <dc:creator>Gil-Martinez, Lidia</dc:creator>
      <dc:creator>Santos Mejías, Alejandro</dc:creator>
      <dc:creator>De la Torre Ramírez, José Manuel</dc:creator>
      <dc:creator>Baños-Arjona, Alberto</dc:creator>
      <dc:creator>Verardo, Vito</dc:creator>
      <dc:creator>Gómez Caravaca, Ana María</dc:creator>
      <dc:subject>brown seaweeds</dc:subject>
      <dc:subject>Box–Behnken design</dc:subject>
      <dc:subject>chlorophenols</dc:subject>
      <dc:description>The optimization of bioactive compound extraction from Fucus vesiculosus using&#xd;
ultrasound-assisted extraction (UAE) via sonotrode was investigated to maximize&#xd;
phenolic recovery and antioxidant activity while promoting a sustainable process. Optimal&#xd;
conditions (40% v/v ethanol in water, 38 min, 36% amplitude) were selected to&#xd;
maximize phenolic recovery while considering environmental and energy sustainability&#xd;
by optimizing extraction efficiency and minimizing solvent and energy usage. HPLCESI-&#xd;
QTOF-MS analysis tentatively identified 25 phenolic compounds, including sulfated&#xd;
phenolic acids, phlorotannins, flavonoids, and halophenols, with some reported for the&#xd;
first time in F. vesiculosus, underscoring the complexity of this alga’s metabolome. The&#xd;
antioxidant activity of the optimized extract was evaluated through FRAP (143.7 μmol&#xd;
TE/g), DPPH (EC50 105.6 μg/mL), and TEAC (189.1 μmol Trolox/g) assays. The optimized&#xd;
process highlights F. vesiculosus as a valuable source of natural antioxidants, with potential&#xd;
applications in biotechnology, cosmetics, and food industries.</dc:description>
      <dc:date>2025-01-15T09:39:15Z</dc:date>
      <dc:date>2025-01-15T09:39:15Z</dc:date>
      <dc:date>2025-01-14</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Gil Martínez, L. et. al.  Mar. Drugs 2025, 23, 40. [https://doi.org/10.3390/md23010040]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/99197</dc:identifier>
      <dc:identifier>10.3390/md23010040</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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