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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/98544">
      <dc:title>Polydopamine Coated Nonspherical Magnetic Nanocluster for Synergistic Dual Magneto-Photothermal Cancer Therapy</dc:title>
      <dc:creator>García García, Gracia</dc:creator>
      <dc:creator>Lázaro Callejón, Marina</dc:creator>
      <dc:creator>Urquiza, Pedro</dc:creator>
      <dc:creator>Romacho, Tania</dc:creator>
      <dc:creator>Delgado, Ángel V.</dc:creator>
      <dc:creator>Iglesias Salto, Guillermo Ramón</dc:creator>
      <dc:subject>dual magneto-photothermal cancer therapy</dc:subject>
      <dc:subject>local hyperthermia</dc:subject>
      <dc:subject>magnetic hyperthermia</dc:subject>
      <dc:description>Local hyperthermia is gaining considerable interest due to its promising antitumor&#xd;
effects. In this context, dual magneto-photothermal cancer therapy holds great promise.&#xd;
For this purpose, the use of nanomaterials has been proposed. Therefore, the aim of this&#xd;
research is to develop a dual magneto-photothermal agent consisting of polydopaminecoated&#xd;
nonspherical magnetic nanoclusters. The physicochemical characterization of the&#xd;
nanoclusters was performed by electron microscopy, electron dispersive X-ray, dynamic&#xd;
light scattering, electrophoretic mobility, thermogravimetric analysis, and Fourier transform&#xd;
infrared spectroscopy. The biocompatibility of the nanoclusters was evaluated using human&#xd;
skin M1 fibroblasts. The potential of the nanoclusters as dual magneto-photothermal&#xd;
agents was investigated by applying an alternating magnetic field (18 kA/m and 165 kHz)&#xd;
and/or NIR laser (850 nm, 0.75 W/cm2). Nanoclusters showed a size of 350 nm consisting&#xd;
of nonspherical magnetic particles of 11 nm completely coated with polydopamine. In&#xd;
addition, they were superparamagnetic and did not significantly affect cell viability at&#xd;
concentrations below 200 μg/mL. Finally, the SAR values obtained for the nanoclusters&#xd;
demonstrated their suitability for magnetotherapy and phototherapy (71 and 41 W/g,&#xd;
respectively), with a synergistic effect when used together (176 W/g). Thus, this work has&#xd;
successfully developed polymeric-coated magnetic nanoclusters with the potential for dual&#xd;
magneto-photothermal cancer therapy.</dc:description>
      <dc:date>2025-01-07T12:40:25Z</dc:date>
      <dc:date>2025-01-07T12:40:25Z</dc:date>
      <dc:date>2024-12-31</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>García García, G. et. al.  Polymers 2025, 17, 85 [https://doi.org/10.3390/polym17010085]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/98544</dc:identifier>
      <dc:identifier>10.3390/polym17010085</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:relation>info:eu-repo/grantAgreement/H2020/MSC/101064263</dc:relation>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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