Osteoporosis: Causes, Mechanisms, Treatment and Prevention: Role of Dietary Compounds Stromsnes, Kristine Martinez Fajardo, Cristian Soto Rodriguez, Silvana Ulrika Kajander, Erika Ria Lupu, Remus Iulian Pozo Rodriguez, Monica Boira Nacher, Balma Font Alberich, Maria Gambini Castell, Marcos Olaso Gonzalez, Gloria Gomez Cabrera, Maria Carmen Gambini, Juan osteoporosis risk factors polyphenols Osteoporosis is a chronic disease that is characterized by a loss of bone density, which mainly affects the microstructure of the bones due to a decrease in bone mass, thereby making them more fragile and susceptible to fractures. Osteoporosis is currently considered one of the pandemics of the 21st century, affecting around 200 million people. Its most serious consequence is an increased risk of bone fractures, thus making osteoporosis a major cause of disability and even premature death in the elderly. In this review, we discuss its causes, the biochemical mechanisms of bone regeneration, risk factors, pharmacological treatments, prevention and the effects of diet, focusing in this case on compounds present in a diet that could have palliative and preventive effects and could be used as concomitant treatments to drugs, which are and should always be the first option. It should be noted as a concluding remark that non-pharmacological treatments such as diet and exercise have, or should have, a relevant role in supporting pharmacology, which is the recommended prescription today, but we cannot ignore that they can have a great relevance in the treatment of this disease. 2024-12-20T10:56:52Z 2024-12-20T10:56:52Z 2024-12-16 journal article Stromsnes, K. et. al. Pharmaceuticals 2024, 17, 1697. [https://doi.org/10.3390/ph17121697] https://hdl.handle.net/10481/98354 10.3390/ph17121697 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI