Clinical Significance of Langerhans Cells in Squamous Cell Carcinoma of the Larynx Esteban, Francisco Ruiz Cabello, Francisco González Moles, Miguel Ángel Lopez Gonzalez, Miguel Angel Funez, Rafael Redondo, Maximino Langerhans cells (LCs) may be involved in the immunosurveillance against tumors as antigen-presenting cells. Our objective has been to determine the relevance of LC in progression of larynx squamous cell carcinomas and their relationship with different subpopulations of tumor-infiltrating cells. LCs were investigated by immunohistochemical methods using anti-CD1 antibody. LCs were detected in most of the primary tumors studied (44 out of 50) and also in metastases (6 out of 10) and recurrences (2 out of 3), but we did not find any statistical association between number of LCs and clinical-pathological parameters or survival. However, the number of LCs was increased in patients with evident infiltration of lymphocytes, mainly cytotoxic T cells. We can conclude that although LCs did not show clinical utility as prognostic marker, they may play a role in releasing an active immune response in larynx carcinomas, according to their ability to present antigens to sensitized T cells. 2024-12-13T10:50:21Z 2024-12-13T10:50:21Z 2012-02-09 journal article Esteban, Francisco, Ruiz-Cabello, Francisco, Gonzalez-Moles, Miguel Angel, Lopez-Gonzalez, Miguel Angel, Funez, Rafael, Redondo, Maximino, Clinical Significance of Langerhans Cells in Squamous Cell Carcinoma of the Larynx, Journal of Oncology, 2012, 753296, 5 pages, 2012. https://doi.org/10.1155/2012/753296 https://hdl.handle.net/10481/97989 10.1155/2012/753296 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Wiley