Microbial antibiotics take the lead in the fight against plant pathogens Roca Hernández, Amalia de la Arrixac Matilla, Miguel A. The plant microbiome is essential for plant fitness and health. Antibiotics produced by plant-associated bacteria have been shown to play an important role in protecting plant hosts against phytopathogens. Here, we highlight the strong biotechnological potential of (i) antibiotic producing plant-associated bacteria as biocontrol agents and (ii) the heterologous expression of antibiotic biosynthetic gene clusters in non-pathogenic plant-associated bacteria. We also provide the complete list of the active substances based on bacteria, fungi, and viruses currently approved or pending approval in the European Union, as an indication of the significant emergence and biotechnological applicability of biopesticides. Further progress in this field of research will enable the development of novel biopesticides for the biocontrol of agricultural pests. 2024-12-04T10:29:20Z 2024-12-04T10:29:20Z 2022-12-05 journal article Roca, A. & Matilla, M.A. (2023) Microbial antibiotics take the lead in the fight against plant pathogens. Microbial Biotechnology, 16, 28–33. Available from: https://doi.org/10.1111/1751-7915.14185 https://hdl.handle.net/10481/97690 10.1111/1751-7915.14185 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Wiley