Microencapsulation, Cream Development, and Controlled Clinical Study of an Upcycled Polyphenolic Extract Combined with sh-Oligopeptide-1 Mayayo, Teo Russo, Gabriella Jiménez-Escobar, Ana Leticia Pérez González, Noelia Clares Naveros, Beatriz Ruiz Martínez, Adolfina Tomás-Cobos, Lidia Valera, Ana Gómez-Farto, Almudena Arias Santiago, Salvador Montero Vílchez, Trinidad upcycling polyphenols sh-oligopeptide-1 Olive mills produce pomace as a by-product of olive oil production process, which has a negative environmental impact. In this study, the dry extract of pomace (OG2), rich in polyphenols, was used for cosmetic purposes. The polyphenolic extract was encapsulated together with sholigopeptide- 1 using cellulose fibres by spray-drying technology. Cytotoxicity and antistress cell studies were carried out using a modified cell line (THP1). Based on the results, a single, randomised, self-controlled study was conducted to evaluate the cream in thirty healthy volunteers. Statistical analysis was performed using a paired samples t-test. Skin moisture increased in the treated forearm (p-value < 0.000). There was an increase in elasticity in the treated forearm (p-value 0.042). TEWL decreased after one week of cream application (p-value 0.099). The results of this clinical study showed that the cream improved barrier function after one week of application on healthy skin. 2024-11-28T12:47:55Z 2024-11-28T12:47:55Z 2024-11-20 journal article Mayayo, T. et. al. Cosmetics 2024, 11, 198. [https://doi.org/10.3390/cosmetics11060198] https://hdl.handle.net/10481/97522 10.3390/cosmetics11060198 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI