Adherence to the 2018 WCRF/AICR cancer prevention guidelines and chronic lymphocytic leukemia in the MCC-Spain study Solans, Marta Romaguera, Dora Gracia-Lavedan, Esther Molinuevo, Amaia Benavente, Yolanda Saez, Marc Marcos-Gragera, Rafael Costas, Laura Robles, Claudia Alonso, Esther De la Banda, Esmeralda Gonzalez-Barca, Eva Llorca, Javier Rodríguez-Suarez, Marta María Lozano Lorca, Macarena Aymerich, Marta Campo, Elias Gimeno-Vázquez, Eva Castaño-Vinyals, Gemma Aragonés, Nuria Pollán, Marina Kogevinas, Manolis De Sanjose, Silvia Amiano, Pilar Casabonne, Delphine Chronic lymphocytic leukemia WCRF/AICR 2018 recommendations Nutrition-based guidelines Case-control study This work was supported by Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporación grant IJCI-2014-20900. Spanish Ministry of Economy and Competitiveness - Carlos III Institute of Health cofunded by FEDER funds/European Regional Develpment Fund (ERDF) - a way to build Europe (grants PI17/01280, PI11/01810, PI14/01219, PI11/02213, PI09/1662, PI15/00966, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, SV-09-CLINIC-1 and CIBERESP) and Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme / Generalitat de Catalunya for institutional support (2017SGR1085). The ICGC CLL-Genome Project was funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII), PMP15/00007 and CIBERONC. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Introduction: Preventable risk factors for chronic lymphocytic leukemia (CLL) remain largely unknown. The aim of this study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and CLL, in the MCC-Spain case–control study. Methods: A total of 318 CLL cases and 1293 population-based controls were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on the 2018 recommendations for cancer prevention (on body fatness, physical activity, and diet) was constructed. We used logistic regression analysis adjusting for potential confounders. Results: Individuals in the highest tertile of the WCRF/AICR score had an odds ratio for CLL of 1.25 (95 % CI 0.91; 1.73) compared with individuals with low adherence (p-trend = 0.172). Each point increment in the score was associated with an OR for CLL of 1.06 (95 % CI 0.91; 1.23). Analyses by severity of disease did not show significant heterogeneity of effects. Conclusion: Overall, our results do not support an association between the WCRF/AICR score and CLL, yet we might have been limited by statistical power and study design to detect modest associations. Further research, ideally with a prospective design, long follow-up, and including additional lymphoma subtypes, is warranted to confirm the impact of composite healthy lifestyle behaviors on lymphoma risk. 2024-11-27T07:32:41Z 2024-11-27T07:32:41Z 2020-02 journal article Solans, Marta et al. Cancer Epidemiology Volume 64, February 2020, 101629. https://doi.org/10.1016/j.canep.2019.101629 https://hdl.handle.net/10481/97415 10.1016/j.canep.2019.101629 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ embargoed access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Elsevier