Safety Level of Microorganism-Bearing Products Applied in Soil-Plant Systems Vassileva, Maria Hristova Mocali, Stefano Canfora, Loredana Malusá, Eligio García del Moral, Luis F. Martos, Vanessa Flor Peregrín, Elena Bojkov Vassilev, Nikolay microbial inoculants pathogens risks of contamination The indiscriminate use of chemical fertilizers adversely affects ecological health and soil microbiota provoking loss of soil fertility and greater pathogen and pest presence in soilplant systems, which further reduce the quality of food and human health. Therefore, the sustainability, circular economy, environmental safety of agricultural production, and health concerns made possible the practical realization of eco-friendly biotechnological approaches like organic matter amendments, biofertilizers, biopesticides, and reuse of agro-industrial wastes by applying novel and traditional methods and processes. However, the advancement in the field of Biotechnology/Agriculture is related to the safety of these microorganism-bearing products. While the existing regulations in this field are well-known and are applied in the preparation and application of waste organic matter and microbial inoculants, more attention should be paid to gene transfer, antibiotic resistance, contamination of the workers and environment in farms and biotech-plants, and microbiome changes. These risks should be carefully assessed, and new analytical tools and regulations should be applied to ensure safe and highquality food and a healthy environment for people working in the field of bio-based soil amendments. 2024-11-21T11:07:26Z 2024-11-21T11:07:26Z 2022-04-28 journal article Vassileva, M. et. al. Front. Plant Sci. 13:862875. [https://doi.org/10.3389/fpls.2022.862875] https://hdl.handle.net/10481/97198 10.3389/fpls.2022.862875 eng info:eu-repo/grantAgreement/EC/H2020/817946 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Frontiers Media