Movement Behaviors and Bone Biomarkers in Young Pediatric Cancer Survivors: A Cross-Sectional Analysis of the iBoneFIT Project Gil Cosano, José Juan Ubago Guisado, Esther Llorente Cantarero, Francisco Jesús Mármol Pérez, Andrés Rodríguez Solana, Andrea Pascual Gázquez, Juan Francisco Mateos, Maria E. Molina-Hurtado, Jose R. García Fontana, Beatriz Narciso, Pedro Henrique Klentrou, Panagiota Gracia-Marco, Luis bone turnover exercise children Background/Objectives: This study aims to investigate the association of movement behaviors with irisin, sclerostin, and bone turnover markers in young pediatric cancer survivors. Methods: A total of 116 young pediatric cancer survivors (12.1 ± 3.3 years; 42% female) were recruited. Time spent in movement behaviors over at least seven consecutive 24 h periods was measured by accelerometers (wGT3x-BT accelerometer, ActiGraph). Blood samples were collected at rest and serum was analyzed for irisin, sclerostin, cross-linked telopeptide of type I collagen (CTX), procollagen type I amino-terminal propeptide (P1NP), total osteocalcin (OC), alkaline phosphatase (ALP), 25-hydroxyvitamin D, parathyroid hormone (PTH), calcium, phosphorous, and magnesium. Results: Irisin and sclerostin were not significantly correlated with bone turnover markers. Sedentary time was negatively correlated with the P1NP (r = −0.411, p = 0.027) and total OC (r = −0.479, p = 0.015) Z-scores, whereas moderate-to-vigorous physical activity was positively correlated with the P1NP (r = 0.418, p = 0.024) and total OC (r = 0.478, p = 0.016) Z-scores. Moreover, total physical activity was positively correlated with the total OC Z-score (r = 0.448, p = 0.025). Finally, the uncoupling index [CTX/P1NP] was positively correlated with sedentary time (r = 0.424, p = 0.012) and negatively correlated with light physical activity (r = −0.352, 0.041). Conclusions: Reducing sedentary time and increasing physical activity may favor bone formation over resorption in young pediatric cancer survivors. 2024-11-19T08:13:34Z 2024-11-19T08:13:34Z 2024-11-16 journal article Gil Cosano, J.J. et. al. Nutrients 2024, 16, 3914. [https://doi.org/10.3390/nu16223914] https://hdl.handle.net/10481/97056 10.3390/nu16223914 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI