<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/97053">
      <dc:title>Design and Characterization of Biomimetic Hybrid Construct Based on Hyaluronic Acid and Alginate Bioink for Regeneration of Articular Cartilage</dc:title>
      <dc:creator>Galocha-León, Cristina</dc:creator>
      <dc:creator>Sntich Acedo, Cristina</dc:creator>
      <dc:creator>Clares Naveros, Beatriz</dc:creator>
      <dc:creator>Voltes Martínez, Ana</dc:creator>
      <dc:creator>Marchal Corrales, Juan Antonio</dc:creator>
      <dc:creator>Gálvez Martín, Patricia</dc:creator>
      <dc:subject>hyaluronic acid</dc:subject>
      <dc:subject>mesenchymal stromal cell</dc:subject>
      <dc:subject>bioprinting</dc:subject>
      <dc:description>Background/Objectives: Three-dimensional bioprinting technology has enabled great&#xd;
advances in the treatment of articular cartilage (AC) defects by the biofabrication of biomimetic&#xd;
constructs that restore and/or regenerate damaged tissue. In this sense, the selection of suitable cells&#xd;
and biomaterials to bioprint constructs that mimic the architecture, composition, and functionality of&#xd;
the natural extracellular matrix (ECM) of the native tissue is crucial. In the present study, a novel&#xd;
cartilage-like biomimetic hybrid construct (CBC) was developed by 3D bioprinting to facilitate and&#xd;
promote AC regeneration. Methods: The CBC was biofabricated by the co-bioprinting of a bioink&#xd;
based on hyaluronic acid (HA) and alginate (AL) loaded with human mesenchymal stromal cells&#xd;
(hMSCs), with polylactic acid supporting the biomaterial, in order to mimic the microenvironment&#xd;
and structural properties of native AC, respectively. The CBC was biologically in vitro characterized.&#xd;
In addition, its physiochemical characteristics were evaluated in order to determine if the presence of&#xd;
hMSCs modified its properties. Results: Results from biological analysis demonstrated that CBC&#xd;
supported the high viability and proliferation of hMSCs, facilitating chondrogenesis after 5 weeks&#xd;
in vitro. The evaluation of physicochemical properties in the CBCs confirmed that the CBC developed&#xd;
could be suitable for use in cartilage tissue engineering. Conclusions: The results demonstrated&#xd;
that the use of bioprinted CBCs based on hMSC-AL/HA-bioink for AC repair could enhance the&#xd;
regeneration and/or formation of hyaline cartilaginous tissue.</dc:description>
      <dc:date>2024-11-19T08:05:16Z</dc:date>
      <dc:date>2024-11-19T08:05:16Z</dc:date>
      <dc:date>2024-11-07</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Galocha León, C. et. al.  Pharmaceutics 2024, 16, 1422. [https://doi.org/10.3390/pharmaceutics16111422]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/97053</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics16111422</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>