Bilateral Correlational Behavior of Pyroglutamate Aminopeptidase I Activity in Rat Photoneuroendocrine Locations During a Standard 12:12 h Light–Dark Cycle Ramírez Sánchez, Manuel Prieto Gómez, Isabel Segarra, Ana Belén Banegas Font, Inmaculada Martínez Cañamero, Magdalena Domínguez Vías, German Durán Ogalla, Raquel Vives Montero, Francisco brain asymmetry intra-hemispheric correlations inter-hemispheric correlations We previously described the circadian variation and bilateral distribution of pyroglutamate aminopeptidase I (pGluPI) activity levels in photoneuroendocrine locations of adult male rats during a standard 12:12 h light–dark cycle. However, the correlational analysis between such locations has not yet been studied. This may provide new data about the unilateral and bilateral functional interaction between photoneuroendocrine locations under light and dark conditions. We analyzed the correlations between locations of a photoneuroendocrine circuit consisting of retina, anterior hypothalamus, superior cervical ganglion, and pineal gland, as well as other related photoneuroendocrine locations: posterior hypothalamus, anterior pituitary, posterior pituitary, occipital cortex, and serum. In particular, we analyzed the correlations between the left retina or the right retina versus the rest of the locations, as well as the correlations between the left and right sides of paired structures at the different time points selected from 12 h light and 12 h dark periods. Also, the profiles of correlational results were compared with the corresponding mean levels. The results demonstrate the complexity of asymmetrical brain behavior. The correlation profile did not always parallel the profile observed with the mean activity values. The diurnal behavior of correlations with the left or right retina differed from one location to another. Likewise, the diurnal variation of correlations between the left and right sides of the paired structures differed between them. Particularly, while most correlations between the left versus right sides of paired structures showed positive values, that of the posterior hypothalamus showed a negative value at 13 h of light period. In addition, except the posterior hypothalamus, most paired locations only correlated significantly with right retina at 07 h of the light period. The results demonstrate the dynamic complexity of brain asymmetry, which represents a challenge for understanding its functional meaning. 2024-11-19T07:33:32Z 2024-11-19T07:33:32Z 2024-11-17 journal article Ramírez Sánchez, M. et. al. Symmetry 2024, 16, 1539. [https://doi.org/10.3390/sym16111539] https://hdl.handle.net/10481/97040 10.3390/sym16111539 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI