Fermented Goat’s Milk Contributes to the Recovery of Iron Deficiency Anemia via Modulation of the Gut Microbiome Soriano Lerma, Ana del Carmen García Burgos, María Muñoz Alférez, María José Crespo-Pérez, Valentín Pérez-Carrasco, Virginia Ortíz-González, Matilde Linde-Rodríguez, Ángel Sánchez-Martin, Victoria Soriano, Miguel García-Salcedo, José Antonio López Aliaga, María Inmaculada This work was financially supported by the local government Junta de Andalucía through PAIDI research groups (BIO344 and AGR206), the Spanish Ministerio de Ciencia e Innovación (ref: PID2020-120481RB-I00/AEI/10.13039/501100011033), the University of Almerí a (ref: PPUENTE2021-006), the University of Granada (PPJIB2020-02), and the Health Institute Carlos III (Acción Estraté gica en Salud, PI21/00497). A.S.-L., V.P.-C., and V.S.-M. were supported by a fellowship from the Spanish Ministerio de Universidades (FPU 17/05413, FPU 20/03952, FPU 16/05822). M.G.-B. was financially supported by the program CONTRATOS PUENTE from the University of Granada. M.O.-G acknowledges the funds received by the F.P.U. fellowship provided by the University of Almería. Iron deficiency anemia (IDA) is a global public health concern affecting 1.6 billion people worldwide. The administration of iron supplements during the treatment of IDA adversely affects the intestinal barrier function and the composition and functionality of the intestinal microbiome, both of which are already altered during IDA. For this reason, it is of great interest to develop nutritional strategies aimed at alleviating these gut alterations associated with IDA and its treatment. In this sense, fermented goat's milk (FGM) was studied due to its nutritional quality. Our findings showed that in anemic animals the consumption of a FGM-based diet, compared to a standard diet, had positive modulatory effects on the intestinal microbiome. FGM-based diet restored intestinal dysbiosis, the intestinal barrier functionality, and bacterial translocation, contributing to a more efficient recovery of IDA. Therefore, FGM is a useful nutritional tool to ease intestinal alterations occurring during IDA and during its treatment. 2024-11-07T12:15:40Z 2024-11-07T12:15:40Z 2023-10-13 journal article Soriano-Lerma A. et al. Fermented Goat's Milk Contributes to the Recovery of Iron Deficiency Anemia via Modulation of the Gut Microbiome. J Agric Food Chem. 2023 Oct 25;71(42):15668-15679. doi: 10.1021/acs.jafc.3c05560 https://hdl.handle.net/10481/96745 10.1021/acs.jafc.3c05560 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional American Chemical Society