<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/96552">
      <dc:title>Skin Barrier Function and Microtopography in Patients with Atopic Dermatitis</dc:title>
      <dc:creator>Pretel Lara, Carlota</dc:creator>
      <dc:creator>Sanabria de la Torre, Raquel</dc:creator>
      <dc:creator>Arias Santiago, Salvador</dc:creator>
      <dc:creator>Montero Vílchez, Trinidad</dc:creator>
      <dc:subject>atopic dermatitis</dc:subject>
      <dc:subject>eczema</dc:subject>
      <dc:subject>homeostasis</dc:subject>
      <dc:description>Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease whose inci dence is increasing. Skin barrier dysfunction plays an important role in this disease. It has been&#xd;
observed that AD patients have higher transepidermal water loss (TEWL) and lower stratum corneum&#xd;
hydration (SCH); however, there is little information about skin microtopography in this pathology.&#xd;
The objective of this study is to evaluate skin barrier dysfunction and structural changes in patients&#xd;
with AD. Methods: A cross-sectional study was conducted including patients with AD. Parameters&#xd;
of skin barrier function were measured (TEWL, temperature, erythema, pH, skin hydration, elasticity)&#xd;
and also other topographical parameters (scaliness, wrinkles, smoothness, surface, contrast, variance)&#xd;
in both healthy skin and flexural eczematous lesions. Results: A total of 32 patients with AD were&#xd;
included in the study. Flexural eczematous lesions had higher erythema (369.12 arbitrary unit (AU)&#xd;
vs. 223.89 AU, p &lt; 0.001), higher TEWL (27.24 g/h/m2 vs. 13.51 g/h/m2&#xd;
, p &lt; 0.001), lower SCH&#xd;
(20.3 AU vs. 31.88 AU, p &lt; 0.001) and lower elasticity (0.56% vs. 0.65%, p = 0.05). Regarding topo graphic parameters, flexural eczematous lesions presented greater scaliness (5.57 SEsc vs. 0.29 SEsc,&#xd;
p = 0.02), greater smoothness (316.98 SEsm vs. 220.95 SEsm p &lt; 0.001), more wrinkles (73.33 SEw vs.&#xd;
62.15 SEw p = 0.03), greater surface area (836.14% vs. 696.31%. p &lt; 0.001), greater contrast (2.02 AU vs.&#xd;
1.31 AU p = 0.01), greater variance (6.22 AU vs. 4.96 AU p &lt; 0.001) and a lower number of cells (105.5&#xd;
vs. 132.5 p &lt; 0.001) compared to unaffected healthy skin, reflecting a decrease in skin quality in AD&#xd;
patients. Conclusions: Both skin barrier function and skin topography are damaged in patients with&#xd;
AD, with differences between healthy skin and flexural eczema.</dc:description>
      <dc:date>2024-11-03T21:07:25Z</dc:date>
      <dc:date>2024-11-03T21:07:25Z</dc:date>
      <dc:date>2024-10-01</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Pretel Lara, C. J. Clin. Med. 2024, 13, 5861. [https://doi.org/10.3390/jcm13195861]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/96552</dc:identifier>
      <dc:identifier>10.3390/jcm13195861</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>