Macrophages in the Context of Muscle Regeneration and Duchenne Muscular Dystrophy Hernández Torres, Francisco Matías Valiente, Lidia Alzas-Gomez, Virginia Eva Aranega, Amelia macrophages inflammation skeletal muscle Macrophages are essential to muscle regeneration, as they regulate inflammation, carry out phagocytosis, and facilitate tissue repair. These cells exhibit phenotypic switching from proinflammatory (M1) to anti-inflammatory (M2) states during muscle repair, influencing myoblast proliferation, differentiation, and myofiber formation. In Duchenne Muscular Dystrophy (DMD), asynchronous muscle injuries disrupt the normal temporal stages of regeneration, leading to fibrosis and failed regeneration. Altered macrophage activity is associated with DMD progression and physiopathology. Gaining insight into the intricate relationship between macrophages and muscle cells is crucial for creating effective therapies aimed at treating this muscle disorder. This review explores the dynamic functions of macrophages in muscle regeneration and their implications in DMD. 2024-10-29T07:46:22Z 2024-10-29T07:46:22Z 2024-09-27 journal article Hernández Torres, F. et. al. Mol. Sci. 2024, 25, 10393. [https://doi.org/10.3390/ijms251910393] https://hdl.handle.net/10481/96427 10.3390/ijms251910393 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI