Gestational weight gain and daily life impact of pregnancy symptoms in healthy women: A multivariable analysis Benito Villena, Rebeca Cano Ibáñez, Naomi Román Gálvez, María Rosario Martín Peláez, Sandra Saeed Khan, Khalid Martínez Galiano, Juan Miguel Mozas Moreno, Juan Amezcua Prieto, María Del Carmen Gestational weight gain Symptoms Healthy pregnancy Daily life impact The WPP was supported by the Fundación para la Investigación Biosanitaria de Andalucía Oriental (FIBAO − IBS) [grant number PI-0350-2018]. Funding for open access charge: Universidad de Granada / CBUA. Objective: To study the relationship between gestational weight gain (GWG) and Daily Life Impact of Pregnancy Symptoms (DLIPS) scores. Methods: A multivariable analysis of a clinical trial (the Walking Preg_Project (WPP), ClinicalTrials.gov NCT03735381) was conducted. The cohort data concerning GWG across gestational trimesters (T1, T2 and T3) was categorized into adequate, excessive, and reduced based on published criteria. DLIPS was measured using the pregnancy symptoms inventory (PSI) a validated tool, across the gestational trimesters. Univariable and multivariable analyses were employed to assess the association between the GWG categories and DLIPS scores in each trimester of pregnancy estimating the β-coefficients and 95% confidence intervals (CI). Results: There were 221 participants in the cohort. DLIPS mean score in the overall sample and within adequate, excessive, and reduced GWG categories significantly increased across pregnancy (p < 0.005). DLIPS mean score was higher in the excessive GWG category compared to adequate and reduced GWG, in T1 and T2 (p = 0.035; p = 0.031, respectively). An excessive GWG at T1 [β-coefficient (95 % CI) = 3.88, (0.84, 6.93)] and T2 [β-coefficient (95 % CI) = 4.47 (1.24; 7.70)] was associated with higher DLIPS score compared to an adequate GWG. Conclusion: The impact of pregnancy symptoms on daily life increased throughout pregnancy, overall. Excessive GWG was associated with daily life impact of pregnancy symptoms, particularly in the first and second trimester. 2024-10-21T10:50:58Z 2024-10-21T10:50:58Z 2024-10-16 journal article R. Benito-Villena et al. European Journal of Obstetrics & Gynecology and Reproductive Biology 303 (2024) 85–90. https://doi.org/10.1016/j.ejogrb.2024.10.023 https://hdl.handle.net/10481/96175 10.1016/j.ejogrb.2024.10.023 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier