Novel ortho-OPE metallofoldamers: bindinginduced folding promoted by nucleating Ag(I)– alkyne interactions Martín Lasanta, Ana Álvarez Cienfuegos Rodríguez, Luis Johnson, Alice Miguel Álvarez, Delia Mota Ávila, Antonio José Orte Gutiérrez, Ángel Ruedas Rama, María José Ribagorda, María Cárdenas, Diego J. Carreño, M. Carmen Echavarren, Antonio M. We have developed a new family of ortho-oligophenylene ethynylene (o-OPE) metallofoldamers. The folding of these helicates is induced by nucleating carbon–metal interactions between Ag(I) cations and the alkynes of the inner core of the o-OPEs. These o-OPEs form metal–organic assemblies where at least three alkyne moieties are held in close proximity to form novel Ag(I)-complexes with the metal ion lodged into the helical cavity. NMR titration experiments and photokinetic studies have provided quantitative data about the thermodynamic and kinetic features of such binding/folding phenomena. X-ray diffraction and DFT studies have been performed to extract structural information on how the Ag(I) cation is accommodated into the cavity. The great simplicity and versatility of these new metallofoldamers open up the possibility to develop novel structures with applications in material science and/or in asymmetric catalysis. 2024-10-08T07:26:26Z 2024-10-08T07:26:26Z 2014-07-29 journal article Martín Lasanta, A. et. al. Chem. Sci., 2014, 5, 4582. [https://doi.org/10.1039/C4SC01988A] https://hdl.handle.net/10481/95659 10.1039/C4SC01988A eng http://creativecommons.org/licenses/by-nc/4.0/ open access Atribución-NoComercial 4.0 Internacional Royal Society of Chemistry