On the single and multiple associations of COVID‑19 post‑acute sequelae: 6‑month prospective cohort study Jiménez Rodríguez, Beatriz María Gutiérrez Fernández, José Ramos Urbina, Eldis María Romero Ortiz, Ana Dolores García Flores, Paula Isabel Santiago Puertas, María Inmaculada Martín‑López, Maria José López Milena, Genaro Fabregas, Rene Morales García, Concepción Medical research is progressing to clarify the full spectrum of sub-acute and long-term effects of the post-COVID-19 syndrome. However, most manuscripts published to date only analyze the effects of post-COVID-19 in patients discharged from hospital, which may induce significant bias. Here, we propose a pioneering study to analyze the single and multiple associations between post-COVID-19 characteristics with up to 6-months of follow-up in hospitalized and non-hospitalized COVID-19 patients. The cohort study was conducted from May to October 2020 at the University Hospital Virgen de la Nieves, the leading hospital assigned for patients with COVID-19 in Granada, Spain. A total of 372 and 217 patients—with 217 and 207 included in the first and second follow-up visits—were referred 2 and 6 months after diagnosing COVID-19, respectively. We find out that post-COVID-19 clinical and mental health impairment symptoms are correlated with patient gender. Logistic adjustments showed strong statistically robust single and multiple associations of demographic, clinical, mental health, X-ray, laboratory indices, and pulmonary function variables. The functional lung tests are good predictors of chest CT imaging abnormalities in elderly patients. Bilateral lung involvement, subpleural reticulum, ground-glass opacity, peripheral lung lesions, and bronchiectasis were the most common findings of the high-resolution computed tomography images. Nonhospitalized patients suffer more severe thromboembolic events and fatigue than those hospitalized. 2024-10-02T11:44:51Z 2024-10-02T11:44:51Z 2022-03-01 journal article Jiménez Rodríguez, B.M. et. al. Sci Rep 12, 3402 (2022). [https://doi.org/10.1038/s41598-022-07433-8] https://hdl.handle.net/10481/95437 10.1038/s41598-022-07433-8 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer Nature