Systems Biology as a Comparative Approach to Understand Complex Gene Expression in Neurological Diseases Díaz Beltrán, Leticia Cano Gutiérrez, Carlos Wall, Dennis P. Esteban, Francisco J. Systems biology Neurological diseases Gene expression Systems biology interdisciplinary approaches have become an essential analytical tool that may yield novel and powerful insights about the nature of human health and disease. Complex disorders are known to be caused by the combination of genetic, environmental, immunological or neurological factors. Thus, to understand such disorders, it becomes necessary to address the study of this complexity from a novel perspective. Here, we present a review of integrative approaches that help to understand the underlying biological processes involved in the etiopathogenesis of neurological diseases, for example, those related to autism and autism spectrum disorders (ASD) endophenotypes. Furthermore, we highlight the role of systems biology in the discovery of new biomarkers or therapeutic targets in complex disorders, a key step in the development of personalized medicine, and we demonstrate the role of systems approaches in the design of classifiers that can shorten the time for behavioral diagnosis of autism. 2024-10-01T12:01:36Z 2024-10-01T12:01:36Z 2013-05-21 journal article Díaz Beltrán, L. et. al. Behav. Sci. 2013, 3, 253–272. [https://doi.org/10.3390/bs3020253] https://hdl.handle.net/10481/95368 10.3390/bs3020253 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI