Nonylphenol and octylphenol in adipose tissue of women in Southern Spain López-Espinosa, María-José Freire Warden, Carmen Arrebola Moreno, Juan Pedro Navea, Noemí Taoufiki, Jamila Fernández Cabrera, Mariana Fátima Ballesteros García, Óscar Prada, Remedios Olea Serrano, Nicolás Nonylphenol Octylphenol Endocrine disrupters Adipose tissue Spain This research was supported by Grants from the Consejería de Salud de la Junta de Andalucía (SAS 07/0133), the Spanish Ministry of Health (FIS 07/0252), Spanish Ministry of Science and Innovation (Programa Juan de la Cierva-FSE y Programa FPU), and the EU Commission (CONTAMED FP7-ENV-212502). Alkylphenols (APs) and AP ethoxylates are environmental contaminants with endocrine disrupting activities in wildlife and humans. They have been largely used in industrial, agricultural, and domestic applications. Despite strong concerns about the consequences of human exposure to endocrine disrupters, little information is available on the presence in humans of compounds such as APs. The aim of the present study was to determine 4-nonylphenol (NP) and 4-octylphenol (OP) residues in adipose tissue of non-occupationally exposed women living in Southern Spain. NP was detected in 100% (n = 20/20) and OP in 23.5% (n = 4/20) of samples, with median levels of 57 and 4.5 ng g−1 adipose tissue, respectively. Body mass index emerged as a determinant of exposure since it was associated with NP levels (p = 0.041). Adipose tissue NP and OP levels are similar to the few data previously published in other countries. This is the first report on NP and OP levels in a population in Southern Spain. Further research is needed to determine trends in human exposure to these compounds and to investigate their consequences. 2024-09-27T09:37:58Z 2024-09-27T09:37:58Z 2009-08 journal article M.J. Lopez-Espinosa et al. Nonylphenol and octylphenol in adipose tissue of women in Southern Spain. Chemosphere 76 (2009) 847–852. https://doi.org/10.1016/j.chemosphere.2009.03.063 https://hdl.handle.net/10481/95200 10.1016/j.chemosphere.2009.03.063 eng info:eu-repo/grantAgreement/EC/EuropeanCommission/FP7-ENV-212502 open access Elsevier