Occupational exposure to pesticides, reproductive hormone levels and sperm quality in young Brazilian men Cremonese, Cleber Piccoli, Camila Pasqualotto, Fabio Clapauch, Ruth Koifman, Rosalina J. Koifman, Sergio Freire, Carmen Pesticides Fungicides Herbicides Reproductive hormones Sperm quality Anogenital distance Agricultural workers This work was partially supported by the Ministry of Health, the Brazilian National Research Council (CNPq) and the CAPES (“Coordenação de Aperfeiçoamento de Pessoal de Nível Superior”). Cleber Cremonese had a CAPES predoctoral grant and Camila Picolli had a CAPES master’s degree grant. Rosalina Jorge Koifman and Fabio Pasqualotto are supported by the CNPq (“Bolsa de Produtividade em Pesquisa”). Carmen Freire had a “Jovens Talentos” grant from the CAPES/CNPq (Science Without Borders Program, grant number A022_2013). The association of occupational exposure to current-use pesticides with reproductive hormones, semen quality, and genital measures was investigated among young men in the South of Brazil. A cross-sectional study was conducted in 99 rural and 36 urban men aged 18–23 years. Information on pesticide use was obtained through questionnaire. Serum and semen samples were analyzed for sex hormones and sperm parameters, respectively, and measurement of anogenital distance (AGD) and testis volume (TV) were performed. Associations were explored using multivariate linear regression. Rural men had poorer sperm morphology, higher sperm count, and lower LH levels relative to urban subjects. Lifetime use of pesticides, especially herbicides and fungicides, was associated with poorer morphology and reduced LH and prolactin, with evidence of a linear pattern. Maternal farming during pregnancy was associated with larger AGD and TV. Chronic occupational exposure to modern pesticides may affect reproductive outcomes in young men. 2024-09-25T09:20:18Z 2024-09-25T09:20:18Z 2017-01 journal article C. Cremonese et al. Occupational exposure to pesticides, reproductive hormone levels and sperm quality in young Brazilian men. Reproductive Toxicology 67 (2017). https://doi.org/10.1016/j.reprotox.2017.01.001 174–185 https://hdl.handle.net/10481/95058 10.1016/j.reprotox.2017.01.001 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier