Towards a More Efficient Breast Cancer Therapy Using Active Human Cell Membrane-Coated Metal–Organic Frameworks Graván, Pablo Rojas Macías, Sara Picchi, Darina Francesca Galisteo González, Francisco Horcajada, Patricia Marchal Corrales, Juan Antonio Metal–organic frameworks Coating Human cell membrane The recent description of well-defined molecular subtypes of breast cancer has led to the clinical development of a number of successful molecular targets. Particularly, triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with historically poor outcomes, mainly due to the lack of effective targeted therapies. Recent progresses in materials science have demonstrated the impressive properties of metal–organic framework nanoparticles (NPs) as antitumoral drug delivery systems. Here, in a way to achieve efficient bio-interfaces with cancer cells and improve their internalization, benchmarked MIL-100(Fe) NPs were coated with cell membranes (CMs) derived from the human TNBC cell line MDA-MB-468. The prepared CMs-coated metal–organic framework (CMs_MIL-100(Fe)) showed enhanced colloidal stability, cellular uptake, and cytotoxicity in MDAMB- 468 cells compared to non-coated NPs, paving the way for these human CMs-coated MIL-100(Fe) NPs as effective targeted therapies against the challenging TNBC. 2024-09-19T09:04:28Z 2024-09-19T09:04:28Z 2024-04-30 journal article Graván, P.; Rojas, S.; Picchi, D.F.; Galisteo-González, F.; Horcajada, P.; Marchal, J.A. Towards aMore Efficient Breast Cancer Therapy Using Active Human CellMembrane-Coated Metal–Organic Frameworks. Nanomaterials 2024, 14, 784. https://doi.org/10.3390/nano14090784 https://hdl.handle.net/10481/94714 10.3390/nano14090784 eng info:eu-repo/grantAgreement/EC/H2020/MSC 860942 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI