<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/94498">
      <dc:title>Bioactive Properties and In Vitro Digestive Release of Cannabidiol (CBD) from Tailored Composites Based on Carbon Materials</dc:title>
      <dc:creator>Zapata, Karol</dc:creator>
      <dc:creator>Vélez, Angie D.</dc:creator>
      <dc:creator>Correa, Jorge A.</dc:creator>
      <dc:creator>Carrasco Marín, Francisco</dc:creator>
      <dc:creator>Rojano, Benjamín A.</dc:creator>
      <dc:creator>Franco, Camilo A.</dc:creator>
      <dc:creator>Cortés, Farid</dc:creator>
      <dc:subject>Bioavailability</dc:subject>
      <dc:subject>Bioactivity</dc:subject>
      <dc:subject>Carbon support</dc:subject>
      <dc:description>The use of carriers to improve cannabidiol (CBD) bioavailability during digestion is at the&#xd;
forefront of research. The main objective of this research was to evaluate CBD bioactivity and develop&#xd;
CBD composites based on tailored carbon support to improve availability under digestive conditions.&#xd;
The antioxidant capacity of CBDwas evaluated using spectrophotometricmethods, and anti-proliferative&#xd;
assays were carried out using human colon carcinoma cells (SW480). Twenty-four composites of CBD +&#xd;
carbon supports were developed, and CBD desorption tests were carried out under simulated digestive&#xd;
conditions. The antioxidant capacity of CBD was comparable to and superior to Butylhydrox-ytoluene&#xd;
(BHT), a commercial antioxidant. CBD reflected an IC-50 of 10,000 mg/L against SW480 cancer cells.&#xd;
CBD in biological systems can increase the shelf life of lipid and protein foods by 7 and 470 days,&#xd;
respectively. Finally, acid carbons showed major CBD adsorption related to electrostatic interactions, but&#xd;
basic carbons showed better delivery properties related to electrostatic repulsion. A tailored composite&#xd;
was achieved with a CBD load of 27 mg/g with the capacity to deliver 1.1 mg, 21.8 mg, and 4 mg to the&#xd;
mouth, stomach, and duodenum during 18 h, respectively. This is a pioneering study since the carriers&#xd;
were intelligently developed to improve CBD release.</dc:description>
      <dc:date>2024-09-16T09:56:42Z</dc:date>
      <dc:date>2024-09-16T09:56:42Z</dc:date>
      <dc:date>2024-08-27</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Zapata, K.; Vélez, A.D.; Correa, J.A.; Carrasco-Marín, F.; Rojano, B.A.; Franco, C.A.; Cortés, F.B. Bioactive Properties and In Vitro Digestive Release of Cannabidiol (CBD) from Tailored Composites Based on Carbon Materials. Pharmaceutics 2024, 16, 1132. https://doi.org/10.3390/pharmaceutics16091132</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/94498</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics16091132</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>