Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders Cerdó, Tomás García Santos, José Antonio Rodríguez-Pöhnlein, Anna García Ricobaraza, María Nieto-Ruiz, Ana García Bermúdez, María Mercedes Campoy Folgoso, Cristina total parenteral nutrition (TPN) gut microbiota dysbiosis pediatric population Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potential use of pre-, pro- and/or synbiotics as promising therapeutic strategies to reduce the risk of severe gastrointestinal disorders and mortality. The findings discussed here highlight the need for more well-designed studies, and harmonize the methods and its interpretation, which are critical to better understand the role of the gut microbiota in PN-related diseases and the development of efficient and personalized approaches based on pro- and/or prebiotics. 2024-09-12T11:18:16Z 2024-09-12T11:18:16Z 2022-11-06 journal article Cerdó, T. et. al. Nutrients 2022, 14, 4691. [https://doi.org/10.3390/nu14214691] https://hdl.handle.net/10481/94401 10.3390/nu1421469 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI