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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/94393">
      <dc:title>Nanoparticles Combining Gene Therapy and Chemotherapy as a Treatment for Gastrointestinal Tumors: A Systematic Review</dc:title>
      <dc:creator>Rodríguez Criado, Jorge</dc:creator>
      <dc:creator>Quiñonero Muñoz, Francisco José</dc:creator>
      <dc:creator>Prados Salazar, José Carlos</dc:creator>
      <dc:creator>Melguizo Alonso, Consolación</dc:creator>
      <dc:subject>Nanotechnology</dc:subject>
      <dc:subject>Gastrointestinal cancer</dc:subject>
      <dc:subject>siRNA</dc:subject>
      <dc:description>Gastrointestinal cancer is one of the greatest challenges for biomedical research, accounting&#xd;
for one-quarter of diagnoses and one-third of deaths nowadays, due to the existence of drug resistance&#xd;
mechanisms that prevent therapeutic efficacy in advanced stages. Nanotechnology has been shown&#xd;
to be an effective strategy for the evasion of this phenomenon, and gene silencing by siRNA makes&#xd;
it possible to decrease the expression of certain genes involved in chemoresistance and tumor&#xd;
progression. Our review analyzed studies published during the last 5 years that combined siRNA&#xd;
gene inhibition and chemotherapy as treatment of different gastrointestinal tumors. This review was&#xd;
carried out by searching PubMed, SCOPUS andWoS databases, where 49 articles were finally selected.&#xd;
The results showed that simultaneous encapsulation of siRNA targeting different genes involved in&#xd;
cancer and chemotherapy were more effective at the preclinical level compared to the administration&#xd;
of both treatments individually. The cytotoxic effect was generated through increased induction of&#xd;
apoptosis derived from the dysregulation of chemoresistance-related pathways, producing a decrease&#xd;
in tumor volume and an increase in survival of mice in in vivo assays. Therefore, the combination of&#xd;
both therapies in the same nanoformulation appears to be an interesting therapeutic strategy for the&#xd;
treatment of gastrointestinal tumors.</dc:description>
      <dc:date>2024-09-12T10:51:55Z</dc:date>
      <dc:date>2024-09-12T10:51:55Z</dc:date>
      <dc:date>2024-09-04</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Rodríguez-Criado, J.; Quiñonero, F.; Prados, J.; Melguizo, C. Nanoparticles Combining Gene Therapy and Chemotherapy as a Treatment for Gastrointestinal Tumors: A Systematic Review. Appl. Sci. 2024, 14, 7872. https://doi.org/10.3390/app14177872</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/94393</dc:identifier>
      <dc:identifier>10.3390/app14177872</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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