Altitude-induced effects on muscular metabolic stress and hypertrophyrelated factors after a resistance training session Feriche Fernández-Castanys, María Belén Schoenfeld, Brad J. Bonitch Góngora, Juan Germán De la Fuente, Blanca Almeida, Filipa Argüelles, Javier Benavente Bardera, Cristina Padial Puche, Paulino Performance Training Strength This work was supported by the Ministry of Science, Innovation and Universities of Spain under Grant DEP2015-64350-P, MINECO/FEDER and PGC2018-097388-B-I00 AEI/FEDER, EU. This study examined the acute effects of exposure to moderate altitude on factors associated with muscular adaptations following whole-body hypertrophy-oriented resistance training (RT) sessions. Thirteen resistance-trained males completed both counterbalanced standard hypertrophic RT sessions (3 sets × 10RM, 2 min rest) at moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Participants rested 72 h between training sessions. Before and after the exercise session, blood samples were obtained for determination of metabolites and ions (lactate, inorganic phosphate, liquid carbon dioxide and calcium) and hormones (testosterone and growth hormone). Session related performance and perception of effort (s-RPE) were also monitored. Results showed no meaningful differences in performance or s-RPE (8.5 ± 1.4 vs 8.6 ± 0.8 respectively for N and H; p = 0.603). All blood variables displayed statistically significant changes throughout the recovery period compared to basal levels (p < 0.05), except for the testosterone. However, no altitude effect was observed in maximal blood lactate, calcium or anabolic hormones (p > 0.05). The reduction observed in the liquid carbon dioxide concentration in H (21.11 ± 1.46 vs 16.19 ± 1.61 mmol·l−1) seems compatible with an increase in buffering capacity. Compared to N, inorganic phosphate displayed lower recovery values after the RT in H (2.89 ± 0.64 vs 2.23 ± 0.60 mg dl−1; p = 0.007). The results of this study do not support an accentuated effect of acute moderate terrestrial hypoxia on metabolic and hormonal factors linked to muscle growth during hypertrophic resistance training. 2024-09-11T10:18:21Z 2024-09-11T10:18:21Z 2019-11-18 journal article Published version: Feriche, B., Schoenfeld, B. J., Bonitch-Gongora, J., de la Fuente, B., Almeida, F., Argüelles, J., Benavente,C & Padial, P. (2020). Altitude-induced effects on muscular metabolic stress and hypertrophy-related factors after a resistance training session. European journal of sport science, 20(8), 1083-1092 https://doi.org/10.1080/17461391.2019.1691270 https://hdl.handle.net/10481/94337 10.1080/17461391.2019.1691270 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley