Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies Melguizo Rodríguez, Lucía Raquel Costela Ruiz, Víctor Javier Manzano-Moreno, Francisco Javier Ruiz Rodríguez, Concepción Illescas Montes, Rebeca Cytokines Diagnosis Oral pathology Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner-and the results of its analysis complement clinical and histopathological findings in the diagnosis of multiple diseases. The objective of this review was to offer an update on the contribution of salivary biomarkers to the diagnosis and prognosis of diseases of the oral cavity, including oral lichen planus, periodontitis, Sjögren's syndrome, oral leukoplakia, peri-implantitis, and medication-related osteonecrosis of the jaw. Salivary biomarkers such as interleukins, growth factors, enzymes, and other biomolecules have proven useful in the diagnosis and follow-up of these diseases, facilitating the early evaluation of malignization risk and the monitoring of disease progression and response to treatment. However, further studies are required to identify new biomarkers and verify their reported role in the diagnosis and/or prognosis of oral diseases. 2024-09-05T07:34:02Z 2024-09-05T07:34:02Z 2020-07 journal article https://hdl.handle.net/10481/93964 10.3390/ijms21145173 eng http://creativecommons.org/licenses/by-nd/4.0/ open access Attribution-NoDerivatives 4.0 Internacional MDPI