L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity Ramírez Contreras, Diego Vázquez Rodríguez, Sergio García García, Amalia Noriega, Lisset Mendoza, Angel Sánchez-Gaytán, Brenda L. Meléndez, Francisco J. Castro, María Eugenia Cárdenas-García, Maura González-Vergara, Enrique citrulline anticancer mixed-copper complexes Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2′-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties. 2024-07-31T07:57:25Z 2024-07-31T07:57:25Z 2024-05-31 journal article Ramírez Contreras, D. et. al. Pharmaceutics 2024, 16, 747. [https://doi.org/10.3390/pharmaceutics16060747] https://hdl.handle.net/10481/93671 10.3390/pharmaceutics16060747 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI