<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/93572">
      <dc:title>Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight/obesity</dc:title>
      <dc:creator>Plaza-Florido, Abel</dc:creator>
      <dc:creator>Olvera-Rojas, Marcos</dc:creator>
      <dc:creator>A. Alcantara, Juan M.</dc:creator>
      <dc:creator>Radom-Aizik, Shlomit</dc:creator>
      <dc:creator>B. Ortega, Francisco</dc:creator>
      <dc:description>Background: Children with overweight/obesity often exhibit alterations in&#xd;
their plasma protein profiles and reduced heart rate variability (HRV). Plasma&#xd;
proteomics is at the forefront of identifying biomarkers for various clinical conditions.&#xd;
We aimed to examine the association between plasma-targeted proteomics&#xd;
involved in cardiovascular health and resting vagal-related HRV&#xd;
parameters in children with overweight/obesity.&#xd;
Methods: Forty-four children with overweight/obesity (10.2 ± 1.1 years old;&#xd;
52% boys) participated in the study. Olink's technology was used to quantify&#xd;
92 proteins involved in cardiovascular health. HRV was measured using a&#xd;
heart rate monitor (Polar RS800CX). Four resting vagal-related HRV parameters&#xd;
were derived in time- and frequency-domain.&#xd;
Results: Eight proteins (KIM1, IgG Fc receptor II-b, IDUA, BOC, IL1RL2,&#xd;
TNFRSF11A, VSIG2, and TF) were associated with at least one out of the four&#xd;
vagal-related HRV parameters (β values ranging from  0.188 to 0.288; all&#xd;
p &lt; .05), while KIM1, IDUA, and BOC associated with ≥ three vagal-related&#xd;
HRV parameters. Multiple hypothesis testing corrections did not reach statistical&#xd;
significance (false discovery rate [FDR >0.05]). Conclusion: Plasma-targeted proteomics suggested novel biomarkers for resting&#xd;
vagal-related HRV parameters in children with overweight/obesity. Future&#xd;
studies using larger cohorts and longitudinal designs should confirm our findings&#xd;
and their potential clinical implications.</dc:description>
      <dc:date>2024-07-29T10:44:49Z</dc:date>
      <dc:date>2024-07-29T10:44:49Z</dc:date>
      <dc:date>2024-06-12</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Plaza Florido, A. et. al. American Journal of Human Biology, e24113. [https://doi.org/10.1002/ajhb.24113]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/93572</dc:identifier>
      <dc:identifier>10.1002/ajhb.24113</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución-NoComercial 4.0 Internacional</dc:rights>
      <dc:publisher>Wiley Online Library</dc:publisher>
   </ow:Publication>
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