Evaluating the advancements in a recently introduced universal adhesive compared to its predecessor Alam, Arefin Yamauti, Monica Almas Chowdhury, Abu Faem Mohammad Wang, Xiaohong Lloret, Pedro A´lvarez Zuñiga Heredia, Enrique Ezra Cifuentes Jiménez, Carolina Cecilia Dua, Rupak Iijima, Masahiro Sano, Hidehiko Adhesive Bond strength Dentin Background/purpose: The dental adhesive market is constantly evolving to meet the demands of dentists and patients, but new products and upgrades should be rigorously evaluated before being used in clinical practice. This study investigated the physicomechanical properties and dentin bonding efficacy of a newly upgraded universal adhesive compared to its predecessor. Materials and methods: Twenty-four molars were divided into four groups (nZ6/group) based on adhesive (new vs. predecessor) and application mode [self-etch (SE) vs. etch-and-rinse (ER)] for evaluating their dentin microtensile bond strength (mTBS), failure pattern, and bonding interface. Additional thirty-six molars’ crowns were perpendicularly sectioned to obtain flat mid-coronal dentin discs. The opposing dentin surfaces of each disc received contrasting treatments (new/predecessor adhesive applied in SE/ER mode), resulting in six interventions. The bonded discs (n Z 6/intervention) were used to assess the adhesives’ survival probability employing a double-sided mTBS test. The other physicomechanical properties examined were adhesives’ oxygen inhibition layer (OIL), viscosity, hardness, elastic modulus, degree of conversion (DC), and in-situ DC. Results: Both adhesive versions showed similar mTBS (P > 0.05), failure pattern (P > 0.05), and survival probability (P > 0.008). ER mode promoted resin tag formation and exhibited a slender adhesive layer for both adhesives. The newer adhesive version showed a thinner adhesive layer in general with narrower OIL (P < 0.001), less viscosity (P < 0.001), higher hardness (P < 0.05), elastic modulus (P < 0.05), DC (P < 0.001), and in-situ DC (P < 0.001). Conclusion: While the newly updated adhesive had superior physicomechanical properties with more fluidity, its dentin bonding efficacy and survival probability were comparable to its predecessor. 2024-07-26T08:34:34Z 2024-07-26T08:34:34Z 2023-12-19 journal article Alam, A. et. al. 19 (2024) 1609e1619. [https://doi.org/10.1016/j.jds.2023.12.004] https://hdl.handle.net/10481/93504 10.1016/j.jds.2023.12.004 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier